Thème :

Environnement et réduction des fardeaux liés aux maladies chroniques

Type de présentation :

Présentation Orale

Titre abstract :

24-hour blood pressure profile in patients with sickle cell disease receiving care in two hospitals in Cameroon: a comparative study

Auteurs :

Christie E.LINONGE^1*, Simeon-PierreChoukem¹, AnastaseDzudie², Eveline D. T.NGOUADJEU³, Yannick DJIEKA¹,CharlotteEPOSSE⁴

 

 

Institutions:

¹Health and Human Development network, Cameroon ; ²Clinical research, education, networking and consultancy group (CRENC) ; ³Douala General Hospital ; ⁴Laquintinie Hospital, Douala

Corresponding authors :

linongechristie@gmail.com

Référence :

CaHReF 2018, Yaoundé Congres hall, 08 – 11 January 2019 , OERF012

Abstract :

Background: Sickle cell disease (SCD) is characterised by a chronic inflammatory state and consequently target organ damage. It has been suggested that abnormal blood pressure (BP) profiles are associated with worse outcomes in patients with SCD but this is less documented.

Objectif: We aimed to assess the 24-hour BP profile in patients with SCD in sub-Saharan Africa.

Methodology: We conducted a hospital-based, cross-sectional, comparative study from January to April 2017. Thirty-four SCD participants aged ≥ 10 years and 34 controls matched for age, sex and body mass index underwent 24 - hour ambulatory blood pressure monitoring (ABPM). Average clinic BP measurements, ABPM profiles, socio-demographic and biochemical characteristics from the two groups were assessed and compared. Data were analysed using EpiInfo version 7.2.

Results:The prevalence of abnormal systolic BP and diastolic BP dipping was higher in the SCD participants than in the control participants (52.9 % vs 23.5%, p = 0.012 and 41.2% vs 11.4%, p = 0.006 respectively). Masked hypertension was only found in the SCD participants (17.6 % vs 0 p = 0.025) and Nocturnal hypertension was more prevalent in the SCD participants (23.5 % vs 5.9 %, p = 0.039). Low estimated glomerular filtration rate was associated with systolic non-dipping in SCD participants (OR: 5.93, 95%CI: 1.00 - 19.64, p = 0.021).

Conclusion/Recommandation:Our results show that patients with SCD have higher abnormal profiles in 24-hour ABPM than in the healthy control subjects. These abnormalities underline an increased risk of target organ damage. ABPM therefore might be recommended for risk stratification of these patients.

Key Words:Sickle cell, blood pressure dipping, Africa