Biochemical analysis of liver enzymes in the managment of disease progression in people living with hiv/aids and co-infected by hiv and hepatitis b virus
AMBASSA AXEL CYRIAQUE ; DJUIDJE NGOUNOUE Marceline ; GUIATEU TAMO IDA MARLENE ; MOUNDIPA FEWOU Paul
CaHReF 20116, Yaoundé Conges hall, 23 – 26 August 2016 , PL072
Liver diseases in HIV infected persons can occur due to hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infections. Co-infection of HIV and HBV is frequently encountered with HIV having negative impact on HBV progression.
Evaluate the importance of biochemical analyses of the liver function in the management of disease progression in people living with HIV/AIDS and co-infected by HIV and hepatitis B virus in Cameroon. Determine Seroprevalence of HIV-HBV co-infection and liver enzymes over time.
Serum of 75 patients positive for HIV was screened for HBsAg by immunochromatographic test in Yaoundé central hospital, from November 2015 to February 2016. Liver enzymes (AST, ALT, CB, TB and γ-GT), as well as CD4 T cell level determination were assessed following the standard procedures. A second blood sample was taken in HIV mono-infected patients and HIV/HBV co-infected after three months. The data was entered and analyzed by using SPSS version 22.1 statistical software and p < 0.05 was considered as statistically significant.
Hepatitis B virus surface antigen (HBsAg) was identified in 12 patients out of 75 HIV-positive patients for a HIV/HBV co- infection prevalence of 16%. Study participants who had HIV-HBV co-infection have raised mean level ALT (p < 0.05), than HIV mono-infected once and the difference was statistically significant. The second blood sample carried out 3 months later has shown significant elevation of AST, ALT, ALP, conjugated bilirubin and total bilirubin, while the γ-GT remained stable over time. There was no statistically significant CD4 count mean difference between HIV mono-infected and HIV-HBV co-infected study participants.
The first blood sample has shown significant elevation of ALT in HIV-HBV co-infected patients. Raised levels of liver enzymes were seen in co-infection during the second sample blood.
Co-infection, HBV, HIV, CD4 T cells, Liver enzymes