Biochemical exploration of the liver in the control of disease in people living with hiv/aids and co-infected by HIV and hepatitis c virus in Cameroon.
GUIATEU TAMO Ida Marlène ; DJUIDJE NGOUNOUE Marceline ; AMBASSA Axel CyriaqueMOUNDIPA FEWOU Paul
CaHReF 20116, Yaoundé Conges hall, 23 – 26 August 2016 , PL071
Viral hepatitis continues to be a major cause of morbidity and mortality in the world in particular those caused by the virus Hepatitis C (HCV) .This study will help fight against viral infection in one way and in the other will help take care of those co- infected with HIV/HCV virus. Co-infection has an influence on liver functioning.
Evaluate the Importance of biochemical exploration of the liver in the control of disease progression in people co-infected by HIV and hepatitis C virus. Determine Seroprevalence of HIV-HCV co-infection and liver enzymes.
This study was an analytical and prospective study. Blood samples of 75 HIV patients from Yaoundé Central Hospital, Cameroon were initially screened with Immuno chromatographic kit for HCV antibody and a second sample was done after three months to control a disease by analyzing of biochemical markers (ALT, AST, ALP, gGT, conjugated Bilirubin, Total Bilirubin). Socio-demographic data were collected using a questionnaire. Data were introduced and analysed using SPSS version 22.1 software. Statistical analysis was performed using x2 test and Pearson correlation, and the statistical significance was set at the threshold p ≤ 0.05.
Anti-hepatitis C virus antibodies (HCV-Ab) were identified in 10 patients out of 75 HIV-positive patients for a HIV/HCV co- infection prevalence of 13.3%. The results obtained shows that the activity of gGT was significantly higher (P <0.0001) in HIV/HCV co-infected patients compared to HIV mono-infected patients. The concentration of total bilirubin was also significantly higher in HIV/HCV co-infected patients (P = 0.015). After three months, none significantly elevation of some parameters (ALT, ALP, gGT, conjugated Bilirubin, Total Bilirubin) has been observed.
Infection with HCV is aggravated in association with HIV, that result can be confirm by increase of g-GT and total bilirubin. From this, Hepatic damage
Liver enzyme, Co-infection, HIV, HCV, control