Anne Rosette SAMBA MOUGNUTOU1
1university of dschang,Cameroon
Background: Greater attention has been paid to the herbal medicine even in developed countries. Medicinal plants, or their extracts, have been used in the prevention and treatment of many diseases. Thymus species are widely used herbal medicinal plants for various diseases throughout the developing world Thymus vulgaris. T. vulgaris is one
Objectif: This study was designed to assess the toxicity profile hydroethanol extract of T. vulgaris. His was investigated in Albino rats due to its use in
Methodology: The 75°hydroethanol extract of T. vulgaris was tested for toxicity study. Wistar rats were randomly divided into control and treatment groups. The doses for acute toxicity study was single dose of 5000 mg/kg body weight of animal. Whereas, subchronic toxicity study daily administration of doses of 60,120, 240 and 460 mg/kg of the 75°hydroethanolic extract T. vulgaris were used for 28 consecutive days. Biochemical and hematological parameters, microscopic examination of liver, kidney and testis tissue and body weight of rats were evaluated following the test period besides recording the signs of toxicity
Results: Acute toxicity study did not reveal any signs of toxicity; hence the LD50) values of extract was determined to be <5 g/kg body weight in rat. There was no significant change (p>0.05) in general body weight. Observations after sub-chronic toxicity included hyperlipidaemia, increased of ALT, AST and creatine at higher doses. The extract did not produce any toxic effect on vital organs. Hydroethanolic extract of Thymus vulgaris could be considered safe at moderate doses.
Conclusion/Recommandation: Based on this study, we conclude that the 75°Hydroethanolic extract of T. vulgaris can be used from treatment in case of typhoid fever because it is relatively nontoxic in rats.
Key Words: Thymus vulgaris, acute toxicity, subchronic toxici