Hotense GONSU KAMGA1, Yves Le Grand NAPA TCHUEDJI2
1Faculty of Medicine and Biomedical Sciences ; 2University of Yaounde I
CaHReF 2018, Yaoundé Congres hall, 08 – 11 January 2019 , OAU033
Background: Candidiasis, has increased morbidity and mortality amongst patients these last years. The therapeutic measures put forward rest on the classes of antifungals. However certain species develop resistance mechanisms towards these antifungals. This has provoked the search and the development for new antifungal molecules.
Objectif: to evaluate the antifungal activity of virgin coconut oil and the white palm kernel oil on the growth of six species of the
Methodology: Antifongigram was carried out by the method of diffusion discs in agar medium according to the recommendations of the Antibiogramm Committee of the French Society for Microbiology. The effects of each vegetable oil and antifungal were evaluated on the growth of Candida species by the method of macrodilution according to the protocol of Clinical Laboratory Standard Institute
Results: Majority of the species tested were resistant to conventional antifungals used. Candida hoemulonii was the most sensitive specie to virgin coconut oil with percentages of inhibitions higher than 50 % when the concentration of oil was only 3.125 mg/mL and a maximum inhibition percentage of 90.10 %. Candida albicans, was the least susceptible species to virgin coconut oil with a maximum growth inhibition percentage of 59.85%. white palm kernel oil which was more active (PË‚0.05) than virgin coconut oil was introduced in the Sabouraud broth and the MIC and MFC obtained with Fluconazole and Nystatin were lower.
Conclusion/Recommandation: These results prove that these oils can be used to develop antifungals drugs.
Key Words: Key Wordss: candidiasis, vegetable oils, combinations,