Thème :

Environnement et réduction des fardeaux liés aux maladies chroniques

Type de présentation :

Présentation Orale

Titre abstract :

24-hour blood pressure profile in patients with Rheumatoid Arthritis in Douala, Cameroon: a comparative cross-sectional study.

Auteurs :

Takeh BRONHILDA¹, Anastase DZUDIE², Marie Solange DOUALLA², Yannick DJIEKA¹, MaximeTINDONG¹, FernandoKEMTA² , Simeon Pierre CHOUKEM²

 

 

 

Institutions:

¹Health and Human Development (2HD) Research Network ; ²Douala General Hospital

Corresponding authors :

btakeh@yahoo.com

Référence :

CaHReF 2018, Yaoundé Congres hall, 08 – 11 January 2019 , OAU066

Abstract :

Background: Rheumatoid arthritis (RA) has been associated with a high cardiovascular risk attributable to chronic inflammation and development of cardiovascular risk factors. High blood pressure (BP) is the major cause of heart and renal disease in sub-Saharan Africa (SSA). Whether BP profile of RA patients differs from normal subjects is unknown.

Objectif: To compare the 24-hour blood pressure profile of patients with rheumatoid arthritis to that of normal subjects.

Methodology: In this cross-sectional study, 20 participants with RA and 20 age, sex and BMI-matched healthy participants underwent a 24-hour Ambulatory blood pressure monitoring. The frequency of abnormal dipping, masked hypertension and nocturnal hypertension was compared between the two groups. Patients also underwent assessment of highly sensitive C-reactive protein (hsCRP) and albuminuria. Data were analysed using Epi Info version 7.

Results: The majority of the participants were females (16, 80 % per group). The median age was 40.5years in the two groups. There was no statistically significant difference in the frequency of systolic blood pressure dippers, non-dippers and reverse dippers between the two groups. There were more diastolic blood pressure dippers in the RA group (65% vs. 30%, p=0.027). Prevalent nocturnal and masked hypertension was similar in both groups. We did not find any factors independently associated with non-dipping blood pressure or nocturnal hypertension in patients.

Conclusion/Recommandation: Our study shows that compared to healthy participants, individuals with RA present with diastolic blood pressure dipping pattern but similar other patterns of blood pressure profile. Large epidemiological studies are warranted to further explore these findings.

Key Words: Rheumatoid arthritis, Blood pressure profile, dippers.