1School of Laboratory technicians, Cameroon
CaHReF 2018, Yaoundé Conges hall, 08 – 11 January 2019 , OAU062
Background: Human Immunodeficiency virus and Helicobacter pylori are associated with significantchronic inflammation of the gastric mucosa. Gastric inflammation is a precursor to many gastrointestinal disorders including atrophic gastritis Atrophic gastritis is usually accompanied by hypochlorhydria, low pepsinogens and high gastrin levels and is a risk condition for Gastric Cancer.
Objectif: We assessed the prevalence of H. pylori infection, AG and acid-free stomach (hypochlorhydria) amongst HIV/AIDS subjects in Yaounde Cameroon.
Methodology: A total of 84 HIV/AIDS subjects were recruited in Yaounde (Cameroon) during January-May 2018. Clinical and socio-demographic data of the subjectswere recorded. An aliquot of 5 ml of blood was aseptically collected for analysis by GastroPanelÂ® (Biohit Oyj, Helsinki, Finland) biomarker test for PGI, PGII, G-17 and H.pylori IgG antibodies. GastroPanel results were interpreted using the software application GastroSoftÂ® (Biohit). Statistical analyses were run by Epi info 7.0. The study was agreed by the Jammot Hospital, Yaounde, and .ethical clearance was obtained from the National Ethics Committee.
Results: A total of 84 subjects were recruited, aged between17-63 years (mean 37.6 ± 8.9 years). H. pyloriseropositivity (IgG? 30 EIU) was detected in 68(81.0%) of the subjects. H. pyloriseropositivity was closely associated with low CD4 counts (p=0.01). Altogether, 26(31.0%) of the subjects presented with AG of the corpus, while, hypochlorhydria (acid-free stomach) was detectedin 32(38.1%) of the patients. AG and hypochlorhydria were associated with low CD4 counts <200Î¼l/l (p=0.01) and (p=0.005), respectively.
Conclusion/Recommandation: Helicobacter.pylori infection, Atrophic Gastritis and acid-free stomach were common among HIV/AIDS patients, associated with an increased risk for Gastric Cancer and impaired absorption of micronutrients and some medicines.
Key Words: Helicobacter pylori, Atrophic gastritis, Hypochlorhydria, HIV