Variation of CD4+ T˗ Lymphocyte Counts and Transaminases in HIV and HIV/Hepatitis B Co˗ infected Patients on Therapy at Nylon Hospital Douala

CaHReF 20116, Yaoundé Conges hall, 23 – 26 August 2016 , PL049

This study was aimed at determining co-infection prevalence of Hepatitis B in HIV patients, the variation of CD4+ counts and liver enzymes in co˗ infection and HIV only infection as well as risk factors.

314 HIV patients took part in our study. Socio-demographic information and history of exposure to risk factors such as scarification, blood transfusion, and unprotected sexual intercourse and alcohol consumption, were obtained through questionnaire. Serological test were done to determine the presence of Hepatitis B surface Antigen (HBsAg), liver enzymes were measured and CD4+ counts evaluated.

Twenty patients (6.4%) tested positive for HBsAg while the remaining 294 patients (93.6%) had HIV only. There was no significant variation in co-infection and mono-infection prevalence by age and sex (p= 0.7405 and p= 0.3361). Most co˗ infected, were in the age group 31 to 45years. In the CD4+ counts class 201-350 , there were more co-infected males than females 7 (2.23%) against 2 (0.64%) p= 0.02. SGPT and SGOT levels, showed no significant difference in mono and co-infection. There was no association with observed risk factors.

Assessing hepatitis B and HIV co˗ infection is primordial as a basis for decisions concerning patient treatment regimen as the clinical course of one affects the other.

hepatitis B virus; Human immunodeficiency co˗ infection