TITRE

Thrombocyte profile in children infested by Plasmodium parasite, and admitted at the “Centre Mère et Enfant de la Fondation Chantal Biya (CME/FCB)” of Yaoundé

AUTEURS

Mlle KENNE ADJOU Lydiane Nelly ; Dr AWONO AMBENE Parfait ; Dr BOULA Angéline ; M. MBEBA Jean

REFERENCES

CaHReF 20116, Yaoundé Conges hall, 23 – 26 August 2016 , PL037

EMAIL
lydianenellyk@yahoo.fr
ABSTRACT

Thrombocytes are one of the important constitutive elements of blood. They play a major role in the process of blood coagulation, more precisely by intervening in primary haemostasis. A decrease in the normal value of thrombocytes, thrombocytopenia impedes the blood coagulation process, leading to haemorrhage. Thrombocytopenia may have multiple causes. It may stem from central, peripheric and sometimes some pathological events which treatment could improve its management. Our study, which was prospective and cross-sectional had as aim, to establish the thrombocyte profile in children infested by Plasmodium parasite, and admitted at the “Centre Mère et Enfant de la Fondation Chantal Biya (CME/FCB)” of Yaounde. This study was carried out from June to September 2015. The analysis of the thrombocyte profile was based on the presence or absence of malaria parasites blood stages on thick films. The haematological parameters were measured with BC-2800 MINDRAY automatic full blood counter. Thrombocytopenia was confirmed by observing thin blood films for the microscopic appearance of platelets. Data analysis was done with the SPSS version 20 software. A total of 384 children less than 5 years were recruited into the study. We obtained 338 children who were not infested and 46 who were infested, depicting a frequency of 12% malaria cases. The mean platelets value in children infested was 149.8 ± 81.4 G/L, while that of non-infested children was 316.6 ± 134.7. The frequency of thrombocytopenia in children infested with malaria was 58.7% (27/46), while that of non-infested children was 9.2% (31/338). Statistical analysis showed a significant difference between the values of children infested and non-infested (p<0.0001). Our findings show that malaria contributes to the occurrence of thrombocytopenia in children less than 5 years. A better management of malaria in cases of thrombocytopenia would contribute to prevent haemorrhagic risks, especially in children.

MOTS CLES

Thrombocytes, thrombocytopenia, malaria, Plasmodium.